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The antibody against HEBP2 was raised in rabbit using the Recombinant Human Heme-binding protein 2 protein (2-205AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against HEBP2 was raised in rabbit using the Recombinant Human Heme-binding protein 2 protein (2-205AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human thyroid tissue using HEBP2 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using HEBP2 Antibody at dilution of 1:1002
| Cat.No | ADC-44912A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HEBP2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Heme-binding protein 2 protein (2-205AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y5Z4 |
Uniprot Id
Q9Y5Z4
Target Species
Human
Target Name
HEBP2
Target Full Name
Heme-binding protein 2
Target Function
Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions.
Target Subcellular Location
Cytoplasm. Mitochondrion.
Target Protein Families
HEBP family
Target Tissue Specificity
Detected in placenta.
Target Research Area
Cell Biology
Target Synonyms
C6orf34; Chromosome 6 open reading frame 34; Hebp2; HEBP2_HUMAN; Heme binding protein 2; Heme-binding protein 2; Placental protein 23; PP23; Protein SOUL; SOUL
Target Background
The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress.
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