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The antibody against ICK was raised in rabbit using the Synthesized non-phosphopeptide derived from Human ICK around the phosphorylation site of tyrosine 159 (T-D-Y(p)-V-S). as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
The antibody against ICK was raised in rabbit using the Synthesized non-phosphopeptide derived from Human ICK around the phosphorylation site of tyrosine 159 (T-D-Y(p)-V-S). as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
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Western blot analysis of extracts from 3T3 cells, treated with PBS (10uM, 60mins), using ICK (Ab-159) antibody.
Western blot analysis of extracts from 293 cells (Lane 2) and cos-7 cells (Lane 3), using ICK (Ab-159) antiobdy. The lane on the left is treated with synthesized peptide.2
| Cat.No | ADC-42552A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ICK |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized non-phosphopeptide derived from Human ICK around the phosphorylation site of tyrosine 159 (T-D-Y(p)-V-S). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UPZ9 |
Uniprot Id
Q9UPZ9
Target Species
Human
Target Name
CILK1
Target Full Name
Serine/threonine-protein kinase ICK
Target Function
Required for ciliogenesis. Phosphorylates KIF3A. Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. May play a key role in the development of multiple organ systems and particularly in cardiac development. Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity.
Target Involvement
Endocrine-cerebroosteodysplasia (ECO)
Target Subcellular Location
Nucleus. Cytoplasm, cytosol. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body.; [Isoform 2]: Cytoplasm.
Target Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Target Tissue Specificity
Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines.
Target Synonyms
CILK1; ICK; KIAA0936Serine/threonine-protein kinase ICK; EC 2.7.11.1; Ciliogenesis associated kinase 1; Intestinal cell kinase; hICK; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MRK
Target Background
Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified.
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