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The antibody against INF2 was raised in rabbit using the Recombinant Human Inverted formin-2 protein (926-1047AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against INF2 was raised in rabbit using the Recombinant Human Inverted formin-2 protein (926-1047AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-04087A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | INF2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Inverted formin-2 protein (926-1047AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q27J81 |
Uniprot Id
Q27J81
Target Species
Human
Target Name
INF2
Target Full Name
Inverted formin-2
Target Function
Severs actin filaments and accelerates their polymerization and depolymerization.
Target Involvement
Focal segmental glomerulosclerosis 5 (FSGS5); Charcot-Marie-Tooth disease, dominant, intermediate type, E (CMTDIE)
Target Subcellular Location
Cytoplasm, perinuclear region.
Target Protein Families
Formin homology family
Target Tissue Specificity
Widely expressed. In the kidney, expression is apparent in podocytes and some tubule cells.
Target Synonyms
C14orf151; C14orf173; CMTDIE; DKFZp762A0214; FLJ22056; FSGS5; HBEAG binding protein 2 binding protein C; HBEBP2 binding protein C; HBEBP2-binding protein C; INF 2; inf2; INF2_HUMAN; Inverted formin 2; Inverted formin FH2 and WH2 domain containing; Inverted formin-2; MGC13251; pp9484
Target Background
This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.
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