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The antibody against IPMK was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human IPMK. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
The antibody against IPMK was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human IPMK. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
$167.00
Western Blot analysis of COS7 cells using IPMK Polyclonal Antibody
| Cat.No | ADC-38387A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IPMK |
| Target Synonyms | 3, 3 antibody; 4 antibody; 6-tetrakisphosphate 5-kinase antibody; Inositol 1 antibody; Inositol 1, 4, 6 tetrakisphosphate 5 kinase antibody; Inositol polyphosphate multikinase antibody; Ipmk antibody; IPMK_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat, Monkey | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the C-terminal region of Human IPMK. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8NFU5 |
Uniprot Id
Q8NFU5
Target Species
Human
Target Name
IPMK
Target Full Name
Inositol polyphosphate multikinase
Target Function
Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate. Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis. Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6).
Target Subcellular Location
Nucleus.
Target Protein Families
Inositol phosphokinase (IPK) family
Target Tissue Specificity
Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.
Target Synonyms
3; 4; 6-tetrakisphosphate 5-kinase; Inositol 1; Inositol 1,3,4,6 tetrakisphosphate 5 kinase; Inositol polyphosphate multikinase; Ipmk; IPMK_HUMAN
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