Rabbit anti-Human JADE1 Polyclonal Antibody

The antibody against JADE1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 210-509 of human JADE1 (NP_079176.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-03077A

Number

Cat.No	ADA-03077A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	JADE1
Target Synonyms	PHF17; JADE1	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse kidney, Mouse liver	Application	ELISA, WB, IF/ICC

Cat.No

ADA-03077A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

JADE1

Target Synonyms

PHF17; JADE1

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse kidney, Mouse liver

Application

ELISA, WB, IF/ICC

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 210-509 of human JADE1 (NP_079176.2).	Target Species	Human
Uniprot ID	Q6IE81	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 210-509 of human JADE1 (NP_079176.2).

Target Species

Human

Uniprot ID

Q6IE81

Immunogen Sequence

Background Information

Uniprot Id

Q6IE81
Target Species

Human
Target Name

JADE1
Target Full Name

Protein Jade-1
Target Function

Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation. May also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.
Target Subcellular Location

Nucleus. Chromosome. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body.
Target Protein Families

JADE family
Target Tissue Specificity

Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.
Target Synonyms

FLJ22479; Gene for apoptosis and differentiation in epithelia; Jade family PHD finger 1; JADE1 ; JADE1_HUMAN; KIAA1807 ; OTTHUMP00000219842; OTTHUMP00000219934; OTTHUMP00000219935; OTTHUMP00000219936; PHD finger protein 17; PHD protein Jade 1; Phf17; Protein Jade 1; Protein Jade-1
Target Background

Enables transcription coactivator activity. Involved in histone acetylation and negative regulation of canonical Wnt signaling pathway. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Located in several cellular components, including ciliary basal body; cytosol; and nuclear speck. Part of histone acetyltransferase complex.

Rabbit anti-Human JADE1 Polyclonal Antibody

Specifications

Immunogen Information

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