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The antibody against JAM-A/CD321/F11R was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 28-238 of human JAM-A/CD321/F11R (NP_058642.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against JAM-A/CD321/F11R was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 28-238 of human JAM-A/CD321/F11R (NP_058642.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-12309A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | JAM-A/CD321/F11R |
| Target Synonyms | JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1; JAM-A/CD321/F11R | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HepG2, Mouse lung, Rat lung, SKOV3 | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 28-238 of human JAM-A/CD321/F11R (NP_058642.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9Y624 | Immunogen Sequence |
Uniprot Id
Q9Y624
Target Species
Human
Target Name
F11R
Target Full Name
Junctional adhesion molecule A
Target Function
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation.; (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.; (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.
Target Subcellular Location
Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.
Target Protein Families
Immunoglobulin superfamily
Target Tissue Specificity
Expressed in endothelium, epithelium and leukocytes (at protein level).
Target Synonyms
CD 321; CD321; CD321 antigen; ESTM33; F11 receptor; F11R; JAM 1; JAM A; JAM; JAM-1; JAM-A; JAM1; JAM1_HUMAN; JAMA; JCAM; Jcam1; Junction adhesion molecule 1; Junction adhesion molecule; mouse; homolog of; Junctional adhesion molecule 1; Junctional adhesion molecule A; KAT; Ly106; PAM 1; PAM-1; PAM1; Platelet adhesion molecule 1; Platelet adhesion molecule; Platelet F11 receptor; PRO301; UNQ264
Target Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
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