Rabbit anti-Human JMY Polyclonal Antibody

Uniprot Id

Q8N9B5

Target Species

Human

Target Name

JMY

Target Full Name

Junction-mediating and -regulatory protein

Target Function

Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.

Target Subcellular Location

Nucleus. Cytoplasm, cytoskeleton.

Target Protein Families

JMY family

Target Synonyms

FLJ37870; Jmy; JMY protein; JMY_HUMAN; junction mediating and regulatory protein ; Junction mediating and regulatory protein p53 cofactor; Junction-mediating and -regulatory protein; MGC163496 ; OTTHUMP00000161976; WAS protein homology region 2 domain containing 1-like 3; WHDC1L3