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The antibody against JMY was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human JMY. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against JMY was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human JMY. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
$167.00
Western Blot analysis of COLO205 cells using JMY Polyclonal Antibody
| Cat.No | ADC-38367A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | JMY |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the C-terminal region of Human JMY. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N9B5 |
Uniprot Id
Q8N9B5
Target Species
Human
Target Name
JMY
Target Full Name
Junction-mediating and -regulatory protein
Target Function
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
Target Subcellular Location
Nucleus. Cytoplasm, cytoskeleton.
Target Protein Families
JMY family
Target Synonyms
FLJ37870; Jmy; JMY protein; JMY_HUMAN; junction mediating and regulatory protein ; Junction mediating and regulatory protein p53 cofactor; Junction-mediating and -regulatory protein; MGC163496 ; OTTHUMP00000161976; WAS protein homology region 2 domain containing 1-like 3; WHDC1L3
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