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The antibody against KBTBD6 was raised in rabbit using the Recombinant Human Kelch repeat and BTB domain-containing protein 6 protein (1-139AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against KBTBD6 was raised in rabbit using the Recombinant Human Kelch repeat and BTB domain-containing protein 6 protein (1-139AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human liver tissue using KBTBD6 Antibody at dilution of 1:1002
| Cat.No | ADC-13745A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KBTBD6 |
| Target Synonyms | KBTB6_HUMAN antibody; KBTBD6 antibody; Kelch repeat and BTB (POZ) domain containing 6 antibody; Kelch repeat and BTB domain-containing protein 6 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Kelch repeat and BTB domain-containing protein 6 protein (1-139AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q86V97 |
Uniprot Id
Q86V97
Target Species
Human
Target Name
KBTBD6
Target Full Name
Kelch repeat and BTB domain-containing protein 6
Target Function
As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation. By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation. Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Synonyms
KBTB6_HUMAN; KBTBD6; Kelch repeat and BTB (POZ) domain containing 6; Kelch repeat and BTB domain-containing protein 6
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