Rabbit anti-Human LAMB3 Polyclonal Antibody

Uniprot Id

Q13751

Target Species

Human

Target Name

LAMB3

Target Full Name

Laminin subunit beta-3

Target Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Target Involvement

Epidermolysis bullosa, junctional, Herlitz type (H-JEB); Generalized atrophic benign epidermolysis bullosa (GABEB); Amelogenesis imperfecta 1A (AI1A)

Target Subcellular Location

Secreted, extracellular space, extracellular matrix, basement membrane.

Target Tissue Specificity

Found in the basement membranes (major component).

Target Synonyms

BM600 125KDA; Epiligrin subunit bata; FLJ99565; Kalinin B1 chain; Kalinin subunit beta; LAM5; LAMB3; LAMB3_HUMAN; Laminin B1k chain; Laminin subunit beta-3; Laminin-5 subunit beta; LAMNB1; Nicein subunit beta

Target Background

The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene.