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The antibody against LEFTY1 was raised in rabbit using the Recombinant Human Left-right determination factor 1 protein (223-260AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against LEFTY1 was raised in rabbit using the Recombinant Human Left-right determination factor 1 protein (223-260AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-12620A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LEFTY1 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Left-right determination factor 1 protein (223-260AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O75610 |
Uniprot Id
O75610
Target Species
Human
Target Name
LEFTY1
Target Full Name
Left-right determination factor 1
Target Function
Required for left-right axis determination as a regulator of LEFTY2 and NODAL.
Target Subcellular Location
Secreted.
Target Protein Families
TGF-beta family
Target Synonyms
LEFTY1; LEFTB; LEFTYB; UNQ278/PRO317Left-right determination factor 1; Left-right determination factor B; Protein lefty-1; Protein lefty-B
Target Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene.
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