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The antibody against LSS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human LSS (NP_002331.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against LSS was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human LSS (NP_002331.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-11069A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LSS |
| Target Synonyms | OSC; APMR4; HYPT14; CTRCT44; LSS | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HepG2 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human LSS (NP_002331.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P48449 | Immunogen Sequence |
Uniprot Id
P48449
Target Species
Human
Target Name
LSS
Target Full Name
Lanosterol synthase
Target Function
Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.
Target Involvement
Cataract 44 (CTRCT44)
Target Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein.
Target Protein Families
Terpene cyclase/mutase family
Target Tissue Specificity
Widely expressed. Expressed in the hair bulb, the outer root sheath and hair matrix of the hair follicle epithelium. Also detected in dermal papilla, epidermis, sweat glands, sebaceous glands, and blood vessels.
Target Research Area
Signal Transduction
Target Synonyms
LSS; OSCLanosterol synthase; EC 5.4.99.7; 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC; hOSC
Target Background
The protein encoded by this gene catalyzes the conversion of (S)-2, 3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.
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