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The antibody against MAPK4 was raised in rabbit using the Recombinant Human Mitogen-activated protein kinase 4 protein (348-587AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against MAPK4 was raised in rabbit using the Recombinant Human Mitogen-activated protein kinase 4 protein (348-587AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human tonsil tissue using MAPK4 Antibody at dilution of 1:1002
| Cat.No | ADC-40215A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MAPK4 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Mitogen-activated protein kinase 4 protein (348-587AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P31152 |
Uniprot Id
P31152
Target Species
Human
Target Name
MAPK4
Target Full Name
Mitogen-activated protein kinase 4
Target Function
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
Target Tissue Specificity
High expression in heart and brain.
Target Synonyms
ERK-4; ERK3; Erk3 related; ERK4; Extracellular signal regulated kinase 4; Extracellular signal-regulated kinase 4; MAP kinase 4; MAP kinase isoform p63; MAPK 4; MAPK4; Mitogen activated protein kinase 4; Mitogen-activated protein kinase 4; MK04_HUMAN; p63 MAPK; p63-MAPK; p63MAPK; PRKM4; Protein kinase; mitogen-activated; 4; Protein-tyrosine kinase ERK3-related; RMNK2
Target Background
Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants.
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