Rabbit anti-Human MPP1 Polyclonal Antibody

Uniprot Id

Q00013

Target Species

Human

Target Name

MPP1

Target Full Name

55 kDa erythrocyte membrane protein

Target Function

Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.

Target Subcellular Location

Cell membrane; Lipid-anchor. Cell projection, stereocilium.

Target Protein Families

MAGUK family

Target Tissue Specificity

Ubiquitous.

Target Synonyms

55 kDa erythrocyte membrane protein; AAG 12; AAG12; Aging associated gene 12; DXS552; DXS552E; EM55_HUMAN; EMP 55; EMP55; Erythrocyte membrane protein p55; Membrane protein; Membrane protein palmitoylated 1 55kDa; Membrane protein palmitoylated 1; Membrane protein; palmitoylated 1; 55kDa; Migration related gene 1; MPP 1; MPP1; MRG 1; MRG1; OTTHUMP00000026054; OTTHUMP00000196176; p55; palmitoylated 1; Palmitoylated erythrocyte membrane protein; Palmitoylated membrane protein 1; PEMP

Target Background

This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene.