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The antibody against MRPL3 was raised in rabbit using the Synthesized peptide derived from Internal of Human MRPL3. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
The antibody against MRPL3 was raised in rabbit using the Synthesized peptide derived from Internal of Human MRPL3. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
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Western blot analysis of extracts from K562 cells, using MRPL3 antibody.
| Cat.No | ADC-41130A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MRPL3 |
| Form | Liquid | Species Reactivity | Human |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from Internal of Human MRPL3. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P09001 |
Uniprot Id
P09001
Target Species
Human
Target Name
MRPL3
Target Full Name
Large ribosomal subunit protein uL3m
Target Involvement
Combined oxidative phosphorylation deficiency 9 (COXPD9)
Target Subcellular Location
Mitochondrion.
Target Protein Families
Universal ribosomal protein uL3 family
Target Synonyms
39S ribosomal protein L3; 39S ribosomal protein L3 mitochondrial; COXPD9; L3mt; Mitochondrial 39S ribosomal protein L3; Mitochondrial 60S ribosomal protein L3; mitochondrial; mitochondrial ribosomal protein; Mitochondrial ribosomal protein L3; MRL3; MRP-L3; MRPL3; RM03_HUMAN; RPML3
Target Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q.
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