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The antibody against MSL2 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase MSL2 protein (341-473AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against MSL2 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase MSL2 protein (341-473AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-03136A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MSL2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human E3 ubiquitin-protein ligase MSL2 protein (341-473AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9HCI7 |
Uniprot Id
Q9HCI7
Target Species
Human
Target Name
MSL2
Target Full Name
E3 ubiquitin-protein ligase MSL2
Target Function
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
Target Protein Families
MSL2 family
Target Synonyms
Male specific lethal 2 homolog (Drosophila); Male specific lethal 2 homolog 1; Male specific lethal 2 homolog; Male specific lethal 2 like 1; Male-specific lethal 2 homolog; Male-specific lethal 2-like 1; Male-specific lethal-2 homolog 1; MSL-2; MSL2; MSL2-like 1; MSL2_HUMAN; MSL2L1; Ring finger protein 184
Target Background
Predicted to enable ubiquitin protein ligase activity. Involved in histone H4-K16 acetylation. Part of MSL complex.
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