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The antibody against MTAP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human MTAP (NP_002442.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against MTAP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human MTAP (NP_002442.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-10692A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MTAP |
| Target Synonyms | BDMF; MSAP; DMSFH; LGMBF; DMSMFH; c86fus; HEL-249; MTAP | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, NIH/3T3, A-549, HT-29 | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human MTAP (NP_002442.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q13126 | Immunogen Sequence |
Uniprot Id
Q13126
Target Species
Human
Target Name
MTAP
Target Full Name
S-methyl-5'-thioadenosine phosphorylase
Target Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Target Involvement
Diaphyseal medullary stenosis with malignant fibrous histiocytoma (DMSMFH)
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
PNP/MTAP phosphorylase family, MTAP subfamily
Target Tissue Specificity
Ubiquitously expressed.
Target Synonyms
5' methylthioadenosine phosphorylase; 5''-methylthioadenosine phosphorylase; BDMF; c86fus; DMSFH; DMSMFH; Epididymis luminal protein 249; HEL 249; LGMBF; MeSAdo phosphorylase; Methylthioadenosine phosphorylase; MSAP; MTA phosphorylase; MTAP; MTAP_HUMAN; MTAPase; S methyl 5 thioadenosine phosphorylase; S methyl 5' thioadenosine phosphorylase; S-methyl-5''-thioadenosine phosphorylase
Target Background
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage pathway of both adenine and methionine. The encoded enzyme is deficient in many cancers. Multiple alternatively spliced transcript variants have been described for this gene.
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