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The antibody against NCF2 was raised in rabbit using the Recombinant Human Neutrophil cytosol factor 2 protein (178-526AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against NCF2 was raised in rabbit using the Recombinant Human Neutrophil cytosol factor 2 protein (178-526AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Immunohistochemistry analysis of human spleen tissue using NCF2 Antibody at dilution of 1:1002
| Cat.No | ADC-09151A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NCF2 |
| Target Synonyms | autosomal 2) antibody; Neutrophil NADPH oxidase factor 2 antibody; NOXA2 antibody; P67 PHOX antibody; p67-phox antibody; p67phox antibody, chronic granulomatous disease | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Neutrophil cytosol factor 2 protein (178-526AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P19878 |
Uniprot Id
P19878
Target Species
Human
Target Name
NCF2
Target Full Name
Neutrophil cytosol factor 2
Target Function
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Target Involvement
Granulomatous disease, chronic, cytochrome-b-positive 2, autosomal recessive (CGD2)
Target Subcellular Location
Cytoplasm.
Target Protein Families
NCF2/NOXA1 family
Target Synonyms
67 kDa neutrophil oxidase factor; Chronic granulomatous disease autosomal 2; FLJ93058; NADPH oxidase activator 2; NCF-2; Ncf2; NCF2_HUMAN; Neutrophil cytosol factor 2; Neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2); Neutrophil NADPH oxidase factor 2; NOXA2; P67 PHOX; p67-phox; p67phox
Target Background
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.
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