Rabbit anti-Human NR1I3 Polyclonal Antibody

Uniprot Id

Q14994

Target Species

Human

Target Name

NR1I3

Target Full Name

Nuclear receptor subfamily 1 group I member 3

Target Function

Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.

Target Subcellular Location

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton.

Target Protein Families

Nuclear hormone receptor family, NR1 subfamily

Target Tissue Specificity

Predominantly expressed in liver.

Target Research Area

Transcription

Target Synonyms

CAR; CAR BETA; CAR1; CARA; Constitutive activator of retinoid response; constitutive active receptor; Constitutive active response; constitutive androstane nuclear receptor variant 2; constitutive androstane nuclear receptor variant 3; constitutive androstane nuclear receptor variant 4; constitutive androstane nuclear receptor variant 5; Constitutive androstane receptor; MB67; MGC97144; NR1I3; NR1I3_HUMAN; Nuclear receptor subfamily 1 group I member 3; orphan nuclear hormone receptor; Orphan nuclear receptor MB67; Orphan nuclear receptor NR1I3

Target Background

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene.