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The antibody against NRARP was raised in rabbit using the Recombinant Human Notch-regulated ankyrin repeat-containing protein (1-114AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against NRARP was raised in rabbit using the Recombinant Human Notch-regulated ankyrin repeat-containing protein (1-114AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human prostate cancer using NRARP Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human endometrial cancer using NRARP Antibody at dilution of 1:1002
| Cat.No | ADC-21771A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NRARP |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Notch-regulated ankyrin repeat-containing protein (1-114AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q7Z6K4 |
Uniprot Id
Q7Z6K4
Target Species
Human
Target Name
NRARP
Target Full Name
Notch-regulated ankyrin repeat-containing protein
Target Function
Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal. Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis. During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain.
Target Protein Families
NRARP family
Target Synonyms
MGC61598; Notch regulated ankyrin repeat containing protein; NOTCH regulated ankyrin repeat protein; Notch-regulated ankyrin repeat-containing protein; nrarp; NRARP_HUMAN
Target Background
Involved in Notch signaling pathway. Acts upstream of or within negative regulation of Notch signaling pathway and positive regulation of canonical Wnt signaling pathway.
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