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The antibody against OAS3 was raised in rabbit using the Recombinant Human 2'-5'-oligoadenylate synthase 3 protein (424-565AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against OAS3 was raised in rabbit using the Recombinant Human 2′-5′-oligoadenylate synthase 3 protein (424-565AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human testis tissue using OAS3 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using OAS3 Antibody at dilution of 1:1002
Immunofluorescent analysis of A549 cells using OAS3 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-11430A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | OAS3 |
| Target Synonyms | 100kDa antibody; OAS3 antibody; OAS3_HUMAN antibody; p100 antibody; p100 OAS antibody; p100OAS antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human 2'-5'-oligoadenylate synthase 3 protein (424-565AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y6K5 |
Uniprot Id
Q9Y6K5
Target Species
Human
Target Name
OAS3
Target Full Name
2'-5'-oligoadenylate synthase 3
Target Function
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
2-5A synthase family
Target Tissue Specificity
Present at high level in placenta trophoblast.
Target Synonyms
(2-5'')oligo(A) synthase 3; 2 5' oligo(A) synthetase 3; 2 5'LIGO; 2 5A synthetase 3; 2''-5''-oligoadenylate synthase 3; 2-5A synthase 3; MGC133260 ; OAS3 2' 5' oligoadenylate synthetase 3, 100kDa ; OAS3; OAS3_HUMAN; p100; p100 OAS; p100OAS
Target Background
This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance.
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