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The antibody against OLFM2 was raised in rabbit using the Human OLFM2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against OLFM2 was raised in rabbit using the Human OLFM2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
$600.00
| Cat.No | ADC-52486A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | OLFM2 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Human OLFM2 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O95897 |
Uniprot Id
O95897
Target Species
Human
Target Name
OLFM2
Target Full Name
Noelin-2
Target Function
Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes. Plays a role in AMPAR complex organization. Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling.
Target Subcellular Location
Secreted. Cell junction, synapse. Membrane. Nucleus. Cytoplasm.
Target Tissue Specificity
Expressed in aortic smooth muscle (at protein level). In the fetus, expressed in the brain and ocular tissues including lens vesicle and optic cup.
Target Synonyms
Neuronal olfactomedin related ER localized protein 2; NOE2; NOE2_HUMAN; Noelin 2; Noelin-2; NOELIN2; NOELIN2 V1; Olfactomedin 2; Olfactomedin-2; OlfC; Olfm2
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