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The antibody against OSMR was raised in rabbit using the Recombinant Human Oncostatin-M-specific receptor subunit beta protein (120-193AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against OSMR was raised in rabbit using the Recombinant Human Oncostatin-M-specific receptor subunit beta protein (120-193AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using OSMR Antibody at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using OSMR Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-10151A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | OSMR |
| Target Synonyms | beta antibody; Oncostatin-M-specific receptor subunit beta antibody; Osmr antibody; OSMR_HUMAN antibody; OSMRB antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Oncostatin-M-specific receptor subunit beta protein (120-193AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q99650 |
Uniprot Id
Q99650
Target Species
Human
Target Name
OSMR
Target Full Name
Oncostatin-M-specific receptor subunit beta
Target Function
Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.
Target Involvement
Amyloidosis, primary localized cutaneous, 1 (PLCA1)
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
Type I cytokine receptor family, Type 2 subfamily
Target Tissue Specificity
Expressed in keratinocytes (at protein level). Expressed at relatively high levels in all neural cells as well as fibroblast and epithelial cells.
Target Synonyms
IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; Interleukin-31 receptor subunit beta; MGC140467; MGC150626; MGC150627; MGC75127; Oncostatin M receptor; Oncostatin M specific receptor subunit beta; Oncostatin M-specific receptor, beta; Oncostatin-M-specific receptor subunit beta; Osmr; OSMR_HUMAN; OSMRB
Target Background
This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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