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The antibody against PAICS was raised in rabbit using the Recombinant Human Multifunctional protein ADE2 protein (176-425AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against PAICS was raised in rabbit using the Recombinant Human Multifunctional protein ADE2 protein (176-425AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human liver tissue using PAICS Antibody at dilution of 1:1002
| Cat.No | ADC-17490A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PAICS |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Multifunctional protein ADE2 protein (176-425AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P22234 |
Uniprot Id
P22234
Target Species
Human
Target Name
PAICS
Target Full Name
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Target Synonyms
ADE2; ADE2H1; AIR carboxylase; AIRC; DKFZp781N1372; MGC1343; MGC5024; Multifunctional protein ADE2; Multifunctional protein ADE2H1; Paics; PAIS; Phosphoribosylaminoimidazole carboxylase; Phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazole succinocarboxamide synthetase; PUR6_HUMAN; SAICAR synthetase
Target Background
This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
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