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The antibody against PDHB was raised in rabbit using the Recombinant Human Pyruvate dehydrogenase E1 component subunit beta, mitochondrial protein (1-300AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against PDHB was raised in rabbit using the Recombinant Human Pyruvate dehydrogenase E1 component subunit beta, mitochondrial protein (1-300AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human gastric cancer using PDHB Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human heart tissue using PDHB Antibody at dilution of 1:1002
| Cat.No | ADC-17277A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PDHB |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Pyruvate dehydrogenase E1 component subunit beta, mitochondrial protein (1-300AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P11177 |
Uniprot Id
P11177
Target Species
Human
Target Name
PDHB
Target Full Name
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Target Function
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Target Involvement
Pyruvate dehydrogenase E1-beta deficiency (PDHBD)
Target Subcellular Location
Mitochondrion matrix.
Target Research Area
Cancer
Target Synonyms
DKFZp564K0164; mitochondrial; ODPB_HUMAN; pdhB; PDHBD; PDHE1 B; PDHE1-B; PHE1B; Pyruvate dehydrogenase (lipoamide) beta; Pyruvate dehydrogenase E1 beta polypeptide; Pyruvate dehydrogenase E1 component subunit beta; Pyruvate dehydrogenase E1 component subunit beta mitochondrial
Target Background
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene.
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