Rabbit anti-Human PLD3 Polyclonal Antibody

Uniprot Id

Q8IV08

Target Species

Human

Target Name

PLD3

Target Full Name

5'-3' exonuclease PLD3

Target Function

5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4. May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting.

Target Involvement

Genetic variants in PLD3 have been suggested to be associated with an increased risk for Alzheimer disease (PubMed:24336208, PubMed:25832409). Further studies, however, did not support PLD3 involvement in this disease (PubMed:25832408, PubMed:25832411, PubMed:25832413, PubMed:25832410, PubMed:26411346).

Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Lysosome lumen. Early endosome membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.

Target Protein Families

Phospholipase D family

Target Tissue Specificity

Widely expressed. In the brain, high levels of expression are detected in the frontal, temporal and occipital cortices and hippocampus. Expressed at low level in corpus callosum.

Target Synonyms

Choline phosphatase 3; HindIII K4L homolog; HU K4; Hu-K4; HUK4; Phosphatidylcholine hydrolyzing phospholipase D3; Phosphatidylcholine-hydrolyzing phospholipase D3; Phospholipase D family; member 3 ; Phospholipase D3; PLD 3; PLD3; PLD3_HUMAN

Target Background

This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene.