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The antibody against POU2F1 was raised in rabbit using the Peptide sequence around aa.270~274(T-P-K-R-I) derived from Human Oct-1. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. This antibody has been validated on ELISA, WB, IF.
The antibody against POU2F1 was raised in rabbit using the Peptide sequence around aa.270~274(T-P-K-R-I) derived from Human Oct-1. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. This antibody has been validated on ELISA, WB, IF.
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Western blot analysis of extracts from JK, HepG2 and 293 cells using Oct-1 Antibody.
Immunofluorescence staining of methanol-fixed NCI-h446 cells showing cytoplasmic staining using Oct-1 Antibody.2
| Cat.No | ADC-43140A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | POU2F1 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Application | ELISA, IF, WB | Storage | Upon receipt |
| Immunogen Description | Peptide sequence around aa.270~274(T-P-K-R-I) derived from Human Oct-1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P14859 |
Uniprot Id
P14859
Target Species
Human
Target Name
POU2F1
Target Full Name
POU domain, class 2, transcription factor 1
Target Function
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.; (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.
Target Subcellular Location
Nucleus.
Target Protein Families
POU transcription factor family, Class-2 subfamily
Target Tissue Specificity
Ubiquitous. Isoform 2 is lymphocyte-specific.
Target Synonyms
FLJ42836; NF A1; NF-A1; Oct 1; Oct 1B; Oct-1; OCT1; Octamer binding protein 1; Octamer binding transcription factor 1; Octamer-binding protein 1; Octamer-binding transcription factor 1; OTF 1; OTF-1; OTF1; OTTHUMP00000032348; OTTHUMP00000032350; OTTHUMP00000032351; PO21; PO2F1; PO2F1_HUMAN; POU class 2 homeobox 1; POU domain class 2 transcription factor 1; POU domain; class 2; transcription factor 1; POU2F1
Target Background
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.
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