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The antibody against RASGRF1 was raised in rabbit using the Recombinant Human Ras-specific guanine nucleotide-releasing factor 1 protein (1-190AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against RASGRF1 was raised in rabbit using the Recombinant Human Ras-specific guanine nucleotide-releasing factor 1 protein (1-190AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using RASGRF1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human small intestine tissue using RASGRF1 Antibody at dilution of 1:1002
| Cat.No | ADC-17311A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RASGRF1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Ras-specific guanine nucleotide-releasing factor 1 protein (1-190AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q13972 |
Uniprot Id
Q13972
Target Species
Human
Target Name
RASGRF1
Target Full Name
Ras-specific guanine nucleotide-releasing factor 1
Target Function
Promotes the exchange of Ras-bound GDP by GTP.
Target Synonyms
CDC25 ; CDC25L; GNRP; GRF1 ; GRF55 ; Guanine nucleotide exchange factor ; Guanine nucleotide releasing factor 55 kD; Guanine nucleotide releasing protein ; guanine nucleotide-releasing factor 1; Guanine nucleotide-releasing protein; H GRF55; HGRF55; PP13187 ; Ras protein specific guanine nucleotide releasing factor 1 ; Ras specific guanine nucleotide releasing factor; Ras specific guanine nucleotide releasing factor CDC25 homolog; Ras specific nucleotide exchange factor CDC25; Ras-GRF1; Ras-specific guanine nucleotide-releasing factor 1; Ras-specific nucleotide exchange factor CDC25; RASGRF1; RGRF1_HUMAN
Target Background
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
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