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The antibody against RNGTT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human RNGTT (NP_003791.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against RNGTT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human RNGTT (NP_003791.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-03028A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RNGTT |
| Target Synonyms | HCE; HCE1; hCAP; CAP1A; RNGTT | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse kidney, Rat brain, 293T, Jurkat, MCF7, Mouse brain, Mouse spleen, THP-1 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human RNGTT (NP_003791.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O60942 | Immunogen Sequence |
Uniprot Id
O60942
Target Species
Human
Target Name
RNGTT
Target Full Name
mRNA-capping enzyme
Target Function
Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
Target Subcellular Location
Nucleus.
Target Protein Families
Non-receptor class of the protein-tyrosine phosphatase family; Eukaryotic GTase family
Target Tissue Specificity
Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle.
Target Synonyms
CAP1A; GTase; GTP--RNA guanylyltransferase; hCAP; HCAP1; HcE; HCE1; MCE1; MCE1_HUMAN; mRNA 5''-triphosphatase; mRNA capping enzyme; mRNA guanyltransferase; mRNA guanylyltransferase; Polynucleotide 5' trisphosphatase; RNA guanylyltransferase and 5' phosphatase; RNGTT; TPase
Target Background
Enables mRNA guanylyltransferase activity and triphosphatase activity. Involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleoplasm.
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