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The antibody against SAE1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-346 of human SAE1 (NP_005491.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against SAE1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-346 of human SAE1 (NP_005491.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00847A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SAE1 |
| Target Synonyms | AOS1; SUA1; UBLE1A; HSPC140; SAE1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, NIH/3T3, B cells, HT-29, K-562, LO2 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-346 of human SAE1 (NP_005491.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9UBE0 | Immunogen Sequence |
Uniprot Id
Q9UBE0
Target Species
Human
Target Name
SAE1
Target Full Name
SUMO-activating enzyme subunit 1
Target Function
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Target Subcellular Location
Nucleus.
Target Protein Families
Ubiquitin-activating E1 family
Target Tissue Specificity
Expression level increases during S phase and drops in G2 phase (at protein level).
Target Research Area
Cell Biology
Target Synonyms
Activator of SUMO1; AOS1; HSPC140; Sae1; SAE1_HUMAN; Sentrin/SUMO activating protein AOS1; SUA1; SUMO 1 activating enzyme E1 N subunit; SUMO 1 activating enzyme subunit 1; SUMO-activating enzyme subunit 1; Ubiquitin like protein SUMO1 activating enzyme; Ubiquitin-like 1-activating enzyme E1A; UBL E1A; UBLE1A
Target Background
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).
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