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The antibody against SDHAF1 was raised in rabbit using the Recombinant Human Succinate dehydrogenase assembly factor 1, mitochondrial protein (78-115AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against SDHAF1 was raised in rabbit using the Recombinant Human Succinate dehydrogenase assembly factor 1, mitochondrial protein (78-115AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human kidney tissue using SDHAF1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using SDHAF1 Antibody at dilution of 1:1002
| Cat.No | ADC-09079A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SDHAF1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Succinate dehydrogenase assembly factor 1, mitochondrial protein (78-115AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | A6NFY7 |
Uniprot Id
A6NFY7
Target Species
Human
Target Name
SDHAF1
Target Full Name
Succinate dehydrogenase assembly factor 1, mitochondrial
Target Function
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3. Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20.
Target Involvement
Mitochondrial complex II deficiency (MT-C2D)
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
Complex I LYR family, SDHAF1 subfamily
Target Tissue Specificity
Ubiquitously expressed.
Target Synonyms
LYR motif containing 8; LYR motif-containing protein 8; LYRM8; mitochondrial; SDH assembly factor 1; SDHAF1; SDHF1_HUMAN; Succinate dehydrogenase assembly factor 1; Succinate dehydrogenase assembly factor 1 mitochondrial; Succinate dehydrogenase complex assembly factor 1
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