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The antibody against SHMT1 was raised in rabbit using the Recombinant Human Serine hydroxymethyltransferase, cytosolic protein (324-483AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against SHMT1 was raised in rabbit using the Recombinant Human Serine hydroxymethyltransferase, cytosolic protein (324-483AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human colon tissue using SHMT1 Antibody at dilution of 1:1002
| Cat.No | ADC-44339A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SHMT1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Serine hydroxymethyltransferase, cytosolic protein (324-483AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P34896 |
Uniprot Id
P34896
Target Species
Human
Target Name
SHMT1
Target Full Name
Serine hydroxymethyltransferase, cytosolic
Target Function
Interconversion of serine and glycine.
Target Subcellular Location
Cytoplasm.
Target Protein Families
SHMT family
Target Synonyms
CSHMT; Cytoplasmic serine hydroxymethyltransferase; cytosolic; GLYC_HUMAN; Glycine hydroxymethyltransferase; Serine hydroxymethyltransferase 1 (soluble); Serine hydroxymethyltransferase; Serine hydroxymethyltransferase; cytosolic; Serine methylase; SHMT; Shmt1
Target Background
This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5, 10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants.
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