Rabbit anti-Human SIGLEC7 Polyclonal Antibody

Uniprot Id

Q9Y286

Target Species

Human

Target Name

SIGLEC7

Target Full Name

Sialic acid-binding Ig-like lectin 7

Target Function

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family

Target Tissue Specificity

Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.

Target Synonyms

Adhesion inhibitory receptor molecule 1; Adhesion inhibitory receptor molecule 1, siglec 7; AIRM 1; AIRM-1; AIRM1; CD328; CD328 antigen; CDw328; D siglec; D-siglec; HLDA 8; p75; p75/AIRM1; QA79; QA79 membrane protein; Sialic acid binding Ig like lectin 7; Sialic acid binding immunoglobulin like lectin 7; Sialic acid-binding Ig-like lectin 7; SIGL7_HUMAN; Siglec-7; SIGLEC19P; SIGLEC7; SIGLECP2

Target Background

Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane.