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The antibody against SMC1B was raised in rabbit using the Recombinant Human Structural maintenance of chromosomes protein 1B protein (954-1060AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against SMC1B was raised in rabbit using the Recombinant Human Structural maintenance of chromosomes protein 1B protein (954-1060AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-03869A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SMC1B |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Structural maintenance of chromosomes protein 1B protein (954-1060AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8NDV3 |
Uniprot Id
Q8NDV3
Target Species
Human
Target Name
SMC1B
Target Full Name
Structural maintenance of chromosomes protein 1B
Target Function
Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.
Target Subcellular Location
Nucleus. Chromosome. Chromosome, centromere.
Target Protein Families
SMC family, SMC1 subfamily
Target Synonyms
bK268H5; SMC protein 1B; SMC-1-beta; SMC-1B; SMC1 beta; SMC1B; SMC1B_HUMAN; SMC1beta; SMC1beta protein; Smc1l2; Structural maintenance of chromosomes 1-like 2; Structural maintenance of chromosomes 1B; Structural maintenance of chromosomes protein 1B
Target Background
SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001 [PubMed 11564881]).
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