Rabbit anti-Human SRRT Polyclonal Antibody

Uniprot Id

Q9BXP5

Target Species

Human

Target Name

SRRT

Target Full Name

Serrate RNA effector molecule homolog

Target Function

Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription.

Target Subcellular Location

Nucleus, nucleoplasm. Cytoplasm.

Target Protein Families

ARS2 family

Target Tissue Specificity

Ubiquitously expressed.

Target Synonyms

ARS2 protein; Arsenate resistance protein ARS2; Arsenite resistance protein 2; Arsenite resistance protein; Arsenite-resistance protein 2; ASR2; MGC126427; Serrate; Serrate RNA effector molecule; Serrate RNA effector molecule homolog (Arabidopsis); Serrate RNA effector molecule homolog; SRRT; SRRT_HUMAN

Target Background

Enables mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Involved in primary miRNA processing. Located in nucleoplasm. Part of ribonucleoprotein complex.