Rabbit anti-Human STRAP Polyclonal Antibody

Uniprot Id

Q9Y3F4

Target Species

Human

Target Name

STRAP

Target Full Name

Serine-threonine kinase receptor-associated protein

Target Function

The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.

Target Subcellular Location

Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus.

Target Protein Families

WD repeat STRAP family

Target Research Area

others

Target Synonyms

MAP activator with WD repeats; MAWD; PTWD; Serine-threonine kinase receptor-associated protein; serine/threonine kinase receptor associated protein; strap; STRAP_HUMAN; UNR-interacting protein; UNRIP; WD 40 repeat protein PT WD; WD-40 repeat protein PT-WD

Target Background

Enables RNA binding activity. Involved in maintenance of gastrointestinal epithelium; negative regulation of transforming growth factor beta receptor signaling pathway; and spliceosomal snRNP assembly. Located in cytosol. Part of SMN complex. Implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm.