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The antibody against SV2B was raised in rabbit using the Recombinant Human Synaptic vesicle glycoprotein 2B protein (1-108AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
The antibody against SV2B was raised in rabbit using the Recombinant Human Synaptic vesicle glycoprotein 2B protein (1-108AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
$299.00
| Cat.No | ADC-23374A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SV2B |
| Target Synonyms | SV2B antibody; KIAA0735 antibody; Synaptic vesicle glycoprotein 2B antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Synaptic vesicle glycoprotein 2B protein (1-108AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q7L1I2 |
Uniprot Id
Q7L1I2
Target Species
Human
Target Name
SV2B
Target Full Name
Synaptic vesicle glycoprotein 2B
Target Function
Probably plays a role in the control of regulated secretion in neural and endocrine cells.; (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction. Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.
Target Subcellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome.
Target Protein Families
Major facilitator superfamily
Target Synonyms
SV2B; KIAA0735; Synaptic vesicle glycoprotein 2B
Target Background
This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients.
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