Rabbit anti-Human TLE1 Polyclonal Antibody

Uniprot Id

Q04724

Target Species

Human

Target Name

TLE1

Target Full Name

Transducin-like enhancer protein 1

Target Function

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

Target Subcellular Location

Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.

Target Protein Families

WD repeat Groucho/TLE family

Target Tissue Specificity

In all tissues examined, mostly in brain, liver and muscle.

Target Synonyms

ESG; ESG1; GRG1; TLE-1; TLE1

Target Background

Enables identical protein binding activity and transcription corepressor activity. Involved in negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of anoikis; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex.