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The antibody against TMLHE was raised in rabbit using the Recombinant Human Trimethyllysine dioxygenase, mitochondrial protein (16-376AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against TMLHE was raised in rabbit using the Recombinant Human Trimethyllysine dioxygenase, mitochondrial protein (16-376AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human kidney tissue using TMLHE Antibody at dilution of 1:1002
| Cat.No | ADC-49918A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TMLHE |
| Target Synonyms | mitochondrial antibody; Trimethyllysine hydroxylase epsilon antibody; XAP130 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Trimethyllysine dioxygenase, mitochondrial protein (16-376AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NVH6 |
Uniprot Id
Q9NVH6
Target Species
Human
Target Name
TMLHE
Target Full Name
Trimethyllysine dioxygenase, mitochondrial
Target Function
Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
Target Involvement
Autism, X-linked 6 (AUTSX6)
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
Gamma-BBH/TMLD family
Target Tissue Specificity
All isoforms, but isoform 8, are widely expressed in adult and fetal tissues. Isoform 8 is restricted to heart and skeletal muscle.
Target Research Area
Metabolism
Target Synonyms
AUTSX6; BBOX2; Butyrobetaine (gamma) 2 oxoglutarate dioxygenase (gamma butyrobetaine hydroxylase) 2; Epsilon-trimethyllysine 2-oxoglutarate dioxygenase; Epsilon-trimethyllysine hydroxylase; FLJ10727; TML dioxygenase; TML hydroxylase; TML-alpha-ketoglutarate dioxygenase; TMLD; TMLH; TMLH_HUMAN; TMLHE; TMLHED; Trimethyllysine dioxygenase, mitochondrial; Trimethyllysine hydroxylase epsilon; XAP130
Target Background
This gene encodes the protein trimethyllysine dioxygenase which is the first enzyme in the carnitine biosynthesis pathway. Carnitine play an essential role in the transport of activated fatty acids across the inner mitochondrial membrane. The encoded protein converts trimethyllysine into hydroxytrimethyllysine. A pseudogene of this gene is found on chromosome X. Alternate splicing results in multiple transcript variants.
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