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The antibody against TRIM6 was raised in rabbit using the Human TRIM6 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against TRIM6 was raised in rabbit using the Human TRIM6 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$600.00
| Cat.No | ADC-46850A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TRIM6 |
| Target Synonyms | TRIM6 antibody; RNF89 antibody; Tripartite motif-containing protein 6 antibody; EC 2.3.2.27 antibody; RING finger protein 89 antibody; RING-type E3 ubiquitin transferase TRIM6 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Human TRIM6 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9C030 |
Uniprot Id
Q9C030
Target Species
Human
Target Name
TRIM6
Target Full Name
Tripartite motif-containing protein 6
Target Function
E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway. In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response. Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells.
Target Subcellular Location
Cytoplasm.
Target Protein Families
TRIM/RBCC family
Target Synonyms
TRIM6; RNF89; Tripartite motif-containing protein 6; EC 2.3.2.27; RING finger protein 89; RING-type E3 ubiquitin transferase TRIM6
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