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The antibody against USP46 was raised in rabbit using the Recombinant Human Ubiquitin carboxyl-terminal hydrolase 46 protein (66-166AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against USP46 was raised in rabbit using the Recombinant Human Ubiquitin carboxyl-terminal hydrolase 46 protein (66-166AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
$299.00
| Cat.No | ADC-02134A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | USP46 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Ubiquitin carboxyl-terminal hydrolase 46 protein (66-166AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P62068 |
Uniprot Id
P62068
Target Species
Human
Target Name
USP46
Target Full Name
Ubiquitin carboxyl-terminal hydrolase 46
Target Function
Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.
Target Protein Families
Peptidase C19 family, USP12/USP46 subfamily
Target Tissue Specificity
Broadly expressed.
Target Synonyms
Deubiquitinating enzyme 46; FLJ11850; FLJ12552; FLJ14283; FLJ39393; Ubiquitin carboxyl terminal hydrolase 46; Ubiquitin carboxyl-terminal hydrolase 46; Ubiquitin specific peptidase 46; Ubiquitin specific processing protease 46; Ubiquitin specific protease 46; Ubiquitin thioesterase 46; Ubiquitin thiolesterase 46; Ubiquitin-specific-processing protease 46; UBP46_HUMAN; USP46
Target Background
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).
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