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The antibody against VLDLR was raised in rabbit using the Recombinant Human Very low-density lipoprotein receptor protein (133-247AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against VLDLR was raised in rabbit using the Recombinant Human Very low-density lipoprotein receptor protein (133-247AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-04987A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | VLDLR |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Very low-density lipoprotein receptor protein (133-247AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P98155 |
Uniprot Id
P98155
Target Species
Human
Target Name
VLDLR
Target Full Name
Very low-density lipoprotein receptor
Target Function
Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation.
Target Involvement
Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 1 (CAMRQ1)
Target Subcellular Location
Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein.
Target Tissue Specificity
Abundant in heart and skeletal muscle; also ovary and kidney; not in liver.
Target Synonyms
FLJ35024; Very low density lipoprotein receptor; Very low-density lipoprotein receptor; VLDL R; VLDL receptor; VLDL-R; VLDLR; VLDLR_HUMAN; VLDLRCH
Target Background
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene.
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