Rabbit anti-Human VTI1A Polyclonal Antibody

Uniprot Id

Q96AJ9

Target Species

Human

Target Name

VTI1A

Target Full Name

Vesicle transport through interaction with t-SNAREs homolog 1A

Target Function

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.

Target Subcellular Location

Cytoplasmic vesicle. Golgi apparatus membrane; Single-pass type IV membrane protein.

Target Protein Families

VTI1 family

Target Synonyms

MMDS3; MVti1; SNARE Vti1a beta protein; Vesicle transport through interaction with t-SNAREs homolog 1A; Vesicle transport through interaction with tSNAREs homolog 1A (yeast); Vesicle transport v-SNARE protein Vti1-like 2; Vti1 rp2; Vti1-rp2; Vti1a; VTI1A vesicle transport through interaction with t-SNAREs 1A; VTI1A_HUMAN; VTI1RP2

Target Background

The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants.