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The antibody against ZBTB16 was raised in rabbit using the Recombinant Human Zinc finger and BTB domain-containing protein 16 protein (126-420AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against ZBTB16 was raised in rabbit using the Recombinant Human Zinc finger and BTB domain-containing protein 16 protein (126-420AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
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Western BlotPositive WB detected in: Mouse Heart tissue lysate, Mouse Brain tissue lysate All lanes: ZBTB16 antibody at 1:500SecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 75,62 kDaObserved band size: 75 kDa
| Cat.No | ADC-10631A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZBTB16 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Zinc finger and BTB domain-containing protein 16 protein (126-420AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q05516 |
Uniprot Id
Q05516
Target Species
Human
Target Name
ZBTB16
Target Full Name
Zinc finger and BTB domain-containing protein 16
Target Function
Acts as a transcriptional repressor. Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Target Involvement
Skeletal defects, genital hypoplasia, and mental retardation (SGYMR)
Target Subcellular Location
Nucleus. Nucleus, nuclear body.
Target Protein Families
Krueppel C2H2-type zinc-finger protein family
Target Tissue Specificity
Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.
Target Synonyms
PLZF; ZNF145
Target Background
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized.
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