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The antibody against FCGRT was raised in rabbit using the Recombinant Macaca fascicularis IgG receptor FcRn large subunit p51 protein (24-297AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against FCGRT was raised in rabbit using the Recombinant Macaca fascicularis IgG receptor FcRn large subunit p51 protein (24-297AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-49426A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FCGRT |
| Target Synonyms | FCGRT antibody; FCRNIgG receptor FcRn large subunit p51 antibody; FcRn antibody; IgG Fc fragment receptor transporter alpha chain antibody; Neonatal Fc receptor antibody | Form | Liquid |
| Species Reactivity | Macaca fascicularis | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Macaca fascicularis IgG receptor FcRn large subunit p51 protein (24-297AA) | Target Species | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8SPV9 |
Uniprot Id
Q8SPV9
Target Species
Cynomolgus Monkey
Target Name
FCGRT
Target Function
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein. Endosome membrane.
Target Protein Families
Immunoglobulin superfamily
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