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The antibody against ply was raised in rabbit using the Recombinant Streptococcus pneumoniae serotype 4 Pneumolysin protein (2-471AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against ply was raised in rabbit using the Recombinant Streptococcus pneumoniae serotype 4 Pneumolysin protein (2-471AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
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| Cat.No | ADC-44000A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ply |
| Target Synonyms | ply antibody; SP_1923 antibody; Pneumolysin antibody; Ply antibody; Thiol-activated cytolysin antibody | Form | Liquid |
| Species Reactivity | Streptococcus pneumoniae serotype 4 | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | HRP conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Streptococcus pneumoniae serotype 4 Pneumolysin protein (2-471AA) | Target Species | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P0C2J9 |
Uniprot Id
P0C2J9
Target Species
Streptococcus pneumoniae serotype 4
Target Name
PLY
Target Function
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation.
Target Subcellular Location
Secreted. Secreted, cell wall. Host cell membrane; Multi-pass membrane protein.
Target Protein Families
Thiol-activated cytolysin family
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