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The antibody against KDM4A was raised in rabbit using the Recombinant Human Lysine-specific demethylase 4A protein (127-364AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against KDM4A was raised in rabbit using the Recombinant Human Lysine-specific demethylase 4A protein (127-364AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human testis tissue using KDM4A Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using KDM4A Antibody at dilution of 1:1002
Immunofluorescent analysis of MCF-7 cells using KDM4A Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-15930A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KDM4A |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Lysine-specific demethylase 4A protein (127-364AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O75164 |
Uniprot Id
O75164
Target Species
Human
Target Name
KDM4A
Target Full Name
Lysine-specific demethylase 4A
Target Function
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.; Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.
Target Subcellular Location
Nucleus.
Target Protein Families
JHDM3 histone demethylase family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
JHDM3A; JmjC domain containing histone demethylation protein 3A; JmjC domain-containing histone demethylation protein 3A; JMJD2; JMJD2A; jumonji C domain containing histone demethylase 3A ; Jumonji domain containing 2; Jumonji domain containing 2A; Jumonji domain containing protein 2A; Jumonji domain-containing protein 2A; KDM4A; KDM4A_HUMAN; KIAA0677; Lysine (K) specific demethylase 4A; Lysine-specific demethylase 4A; TDRD14A; Tudor domain containing 14A
Target Background
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
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