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The antibody against FTCD was raised in rabbit using the Recombinant Human Formimidoyltransferase-cyclodeaminase protein (412-541AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against FTCD was raised in rabbit using the Recombinant Human Formimidoyltransferase-cyclodeaminase protein (412-541AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human liver tissue using FTCD Antibody at dilution of 1:1002
| Cat.No | ADC-16506A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FTCD |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Formimidoyltransferase-cyclodeaminase protein (412-541AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O95954 |
Uniprot Id
O95954
Target Species
Human
Target Name
FTCD
Target Full Name
Formimidoyltransferase-cyclodeaminase
Target Function
Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.; Binds and promotes bundling of vimentin filaments originating from the Golgi.
Target Involvement
Glutamate formiminotransferase deficiency (FIGLU-URIA)
Target Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus. Note=More abundantly located around the mother centriole.
Target Protein Families
Cyclodeaminase/cyclohydrolase family; Formiminotransferase family
Target Research Area
Others
Target Synonyms
Formimidoyltetrahydrofolate cyclodeaminase; Formimidoyltransferase cyclodeaminase; Formiminotetrahydrofolate cyclodeaminase; Formiminotransferase cyclodeaminase; Formiminotransferase-cyclodeaminase; FTCD; FTCD_HUMAN; Glutamate formiminotransferase; Glutamate formyltransferase; LCHC 1; LCHC1
Target Background
The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.
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