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The antibody against RPRD1A was raised in rabbit using the Recombinant Human Regulation of nuclear pre-mRNA domain-containing protein 1A protein (2-276AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against RPRD1A was raised in rabbit using the Recombinant Human Regulation of nuclear pre-mRNA domain-containing protein 1A protein (2-276AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-18668A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RPRD1A |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Regulation of nuclear pre-mRNA domain-containing protein 1A protein (2-276AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96P16 |
Uniprot Id
Q96P16
Target Species
Human
Target Name
RPRD1A
Target Full Name
Regulation of nuclear pre-mRNA domain-containing protein 1A
Target Function
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
Target Protein Families
UPF0400 (RTT103) family
Target Synonyms
C77387; CDKN2B-related protein; Cyclin dependent kinase 2B inhibitor related protein; Cyclin dependent kinase inhibitor 2B related protein (p15INK4B related protein) ; Cyclin dependent kinase inhibitor 2B related protein; Cyclin dependent kinase inhibitor related protein; Cyclin-dependent kinase inhibitor 2B-related protein; FLJ10656; HsT3101; Hypothetical protein FLJ10656; KIAA4077; MGC19513; MGC29396; MGC36325; mKIAA4077; p15INK4B related protein; p15INK4B-related protein; Putative uncharacterized protein P15RS; Regulation of nuclear pre mRNA domain containing 1A; Regulation of nuclear pre-mRNA domain-containing protein 1A; RGD1307374; RPR1A_HUMAN; RPRD1A
Target Background
This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16.
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