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The antibody against TTLL6 was raised in rabbit using the Recombinant Human Tubulin polyglutamylase TTLL6 protein (121-310AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against TTLL6 was raised in rabbit using the Recombinant Human Tubulin polyglutamylase TTLL6 protein (121-310AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-19212A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TTLL6 |
| Target Synonyms | TTLL6 antibody; TTL.6 antibody; Tubulin polyglutamylase TTLL6 antibody; EC 6.-.-.- antibody; Tubulin--tyrosine ligase-like protein 6 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Tubulin polyglutamylase TTLL6 protein (121-310AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N841 |
Uniprot Id
Q8N841
Target Species
Human
Target Name
TTLL6
Target Full Name
Tubulin polyglutamylase TTLL6
Target Function
Polyglutamylase which modifies both tubulin and non-tubulin proteins, generating alpha-linked polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues of target proteins. Preferentially mediates ATP-dependent long polyglutamate chain elongation over the initiation step of the polyglutamylation reaction. Preferentially modifies the alpha-tubulin tail over a beta-tail. Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions. Mediates microtubule polyglutamylation in primary cilia axoneme, which is important for ciliary structural formation and motility. Mediates microtubule polyglutamylation in motile cilia, necessary for the regulation of ciliary coordinated beating. Polyglutamylates non-tubulin protein nucleotidyltransferase CGAS, leading to CGAS DNA-binding inhibition, thereby preventing antiviral defense response.
Target Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body.
Target Protein Families
Tubulin--tyrosine ligase family
Target Synonyms
TTLL6; TTL.6; Tubulin polyglutamylase TTLL6; EC 6.-.-.-; Tubulin--tyrosine ligase-like protein 6
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